Efficient codon optimization with motif engineering
نویسندگان
چکیده
منابع مشابه
Efficient Codon Optimization with Motif Engineering
Abstract. It is now common to add protein coding genes into cloning vectors for expression within non-native host organisms. Codon optimization supports translational efficiency of the desired protein product, by exchanging codons which are rarely found in the host organism with more frequently observed codons. Motif engineering, such as removal of restriction enzyme recognition sites or additi...
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Codon optimization enhances the efficiency of DNA expression vectors used in DNA vaccination and gene therapy by increasing protein expression. Additionally, certain nucleotide motifs have experimentally been shown to be immuno-stimulatory while certain others immuno-suppressive. In this paper, we present algorithms to locate a given set of immuno-modulatory motifs in the DNA expression vectors...
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ژورنال
عنوان ژورنال: Journal of Discrete Algorithms
سال: 2012
ISSN: 1570-8667
DOI: 10.1016/j.jda.2012.04.017